Inherited Apolipoprotein A-V Deficiency in Severe Hypertriglyceridemia

Inherited apolipoprotein A-V deficiency in severe hypertriglyceridemia.

OBJECTIVE Mutations in LPL or APOC2 genes are recognized causes of inherited forms of severe hypertriglyceridemia. However, some hypertrigliceridemic patients do not have mutations in either of these genes. Because inactivation or hyperexpression of APOA5 gene, encoding apolipoprotein A-V (apoA-V), causes a marked increase or decrease of plasma triglycerides in mice, and because some common pol...

Apolipoprotein A-V Deficiency Enhances Chylomicron

9 10 11 12 13 14 15 Linda S. Zhang 1 , Min Xu 1 , Qing Yang 1 , Robert O. Ryan 2 , Philip Howles 1 , Patrick Tso 1 16 17 18 19 20 21 22 23 1. Department of Pathology and Laboratory Medicine, University of Cincinnati College of 24 Medicine, Cincinnati, OH 45215 25 2. Children's Hospital Oakland Research Institute, Oakland, CA 94609 26 27 28 29 Running Head: ApoA-V Deficiency Enhances Chylomicron...

Apolipoprotein A5 and hypertriglyceridemia.

Hypertriglyceridemia is associated with increased risk of coronary heart disease (CHD) (1–5), and it is an integral component of the overlapping syndromes of familial combined hyperlipidemia, insulin resistance syndrome, atherogenic lipoprotein profile, and hyperapobetalipoproteinemia (6 ). More than one mechanism may be involved in the increased risk of CHD associated with increased serum trig...

A Pregnant Woman with Factor V Deficiency

An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients.

Apolipoprotein A-V (apoA-V) is an important regulator of plasma levels of triglyceride (TG) in mice. In humans, APOA5 genetic variation is associated with TG in several populations. In this study, we determined the effects of the p.185Gly>Cys (c.553G>T; rs2075291) polymorphism on plasma TG levels in subjects of Chinese ancestry living in the United States and in a group of non-Chinese Asian anc...